25th November 2012 , 02:00 BST
Guerrero's WBC World Interim Welterweight strap is on the line as the 29-year-old Mexican-born California southpaw looks to cement his full WBC credentials against Miami-based Haitian-American Andre Berto, also 29.
The two men will step into the Citizens Business Bank Arena ring with similar records as the interim champ Guerrero is 30 - 1 - 1, while Berto has 28 wins for one defeat. The stage is set for another belter of a Golden Boy Promotions card live and exclusive on BoxNation.
Nicknamed "The Ghost", the Mexican southpaw has previously held IBF honours at feather and super-featherweight before winning the interim WBA and WBO World Lightweight crowns.
His next move was a vast one, stepping up to the 147lb division after 15 months away from the ring and defeating Selcuk Aydin with a hardworking 12-round decision.
And now he takes on Berto, a natural welterweight and former WBC World champ, in what will be one of the biggest challenges of his career.
For two-time welterweight world champion Andre Berto, a shot at the interim strap presents him with a chance to build his way back to full honours.
The Haitian-American was a dominant force in the welterweight division, winning the WBC crown in 2008 and defending it on several occasions.
However, in April 2011, Berto surrendered his WBC strap to Victor Ortiz in a fiery encounter where both fighters were dropped to the canvas, and eventual winner Ortiz was docked a point in the 10th. The challenger still took a unanimous decision, and left Berto with a first career defeat.
On the road to recovery, the 29-year-old has since beaten Jan Zaveck to secure the IBF Welterweight title, and will now hope to add the interim WBC to his honour roll.