The interim IBO Light-Heavyweight Title
Southpaw Mikhalkin knows he cannot afford another loss as he attempts to rebuild his career having celebrated his 34th birthday last month.
In March last year he faced Sergey Kovalev at Madison Square Garden, but was beaten inside seven rounds.
The Hamburg-based Russian, who is ranked at 14 by the WBO, hasn’t boxed since September when he defeated Bernard Donfack inside two rounds.
He is a former European Champion and other good names on his record include Thomas Oosthuizen and recent World Title challenger Doudou Ngumbu, who he has beaten three times.
Fellow Russian Nikarkhoev is based in Belgium and warmed up for this assignment last month by outpointing one-time prospect Geard Ajetovic.
The current IBO Champion awaiting the winner is Swede Sven Forling who is recovering from injury.
Mikhalkin has other options and is also mandatory contender for the EBU crown held by Dominic Boesel.